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Mechanism of Binding to Ebola Virus Glycoprotein by the ZMapp, ZMAb, and MB-003 Cocktail Antibodies

Cocktails of monoclonal antibodies (MAbs) that target the surface glycoprotein (GP) of Ebola virus (EBOV) are effective in nonhuman primate models and have been used under emergency compassionate-treatment protocols in human patients. However, the amino acids that form the detailed binding epitopes...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Davidson, Edgar, Bryan, Christopher, Fong, Rachel H., Barnes, Trevor, Pfaff, Jennifer M., Mabila, Manu, Rucker, Joseph B., Doranz, Benjamin J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621129/
https://ncbi.nlm.nih.gov/pubmed/26311869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01490-15
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