Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis

The hepatitis C virus (HCV) envelope glycoproteins E1 and E2 form a non-covalently linked heterodimer on the viral surface that mediates viral entry. E1, E2 and the heterodimer complex E1E2 are candidate vaccine antigens, but are technically challenging to study because of difficulties in producing...

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Vydáno v:PLoS Pathog
Hlavní autoři: Gopal, Radhika, Jackson, Kelli, Tzarum, Netanel, Kong, Leopold, Ettenger, Andrew, Guest, Johnathan, Pfaff, Jennifer M., Barnes, Trevor, Honda, Andrew, Giang, Erick, Davidson, Edgar, Wilson, Ian A., Doranz, Benjamin J., Law, Mansun
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749897/
https://ncbi.nlm.nih.gov/pubmed/29253863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006735
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