Mu Opioid Receptors on Primary Afferent Nav1.8 Neurons Contribute to Opiate-Induced Analgesia: Insight from Conditional Knockout Mice

Opiates are powerful drugs to treat severe pain, and act via mu opioid receptors distributed throughout the nervous system. Their clinical use is hampered by centrally-mediated adverse effects, including nausea or respiratory depression. Here we used a genetic approach to investigate the potential o...

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Bibliographic Details
Main Authors: Weibel, Raphaël, Reiss, David, Karchewski, Laurie, Gardon, Olivier, Matifas, Audrey, Filliol, Dominique, Becker, Jérôme A. J., Wood, John N., Kieffer, Brigitte L., Gaveriaux-Ruff, Claire
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3771900/
https://ncbi.nlm.nih.gov/pubmed/24069332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074706
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