Mu Opioid Receptors on Primary Afferent Nav1.8 Neurons Contribute to Opiate-Induced Analgesia: Insight from Conditional Knockout Mice

Opiates are powerful drugs to treat severe pain, and act via mu opioid receptors distributed throughout the nervous system. Their clinical use is hampered by centrally-mediated adverse effects, including nausea or respiratory depression. Here we used a genetic approach to investigate the potential o...

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Autori principali: Weibel, Raphaël, Reiss, David, Karchewski, Laurie, Gardon, Olivier, Matifas, Audrey, Filliol, Dominique, Becker, Jérôme A. J., Wood, John N., Kieffer, Brigitte L., Gaveriaux-Ruff, Claire
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3771900/
https://ncbi.nlm.nih.gov/pubmed/24069332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074706
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