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mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin
The mTOR Complex 1 (mTORC1) protein kinase promotes growth and is the target of rapamycin, a clinically useful drug that also prolongs lifespan in model organisms. A persistent mystery is why the phosphorylation of many bona fide mTORC1 substrates is resistant to rapamycin. We find that the in vitro...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3771538/ https://ncbi.nlm.nih.gov/pubmed/23888043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1236566 |
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