Protecting a transgene expression from the HAC-based vector by different chromatin insulators

Human artificial chromosomes (HACs) are vectors that offer advantages of capacity and stability for gene delivery and expression. Several studies have even demonstrated their use for gene complementation in gene-deficient recipient cell lines and animal transgenesis. Recently, we constructed an adva...

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Hauptverfasser: Lee, Nicholas CO, Kononenko, Artem V., Lee, Hee-Sheung, Tolkunova, Elena N., Liskovykh, Mikhail A., Masumoto, Hiroshi, Earnshaw, William C., Tomilin, Alexey N., Larionov, Vladimir, Kouprina, Natalay
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Basel 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3771377/
https://ncbi.nlm.nih.gov/pubmed/23677492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-013-1362-9
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