Biocatalytic Synthesis of Pikromycin, Methymycin, Neomethymycin, Novamethymycin, and Ketomethymycin

A biocatalytic platform that employs the final two monomodular type I polyketide synthases (PKS) of the pikromycin pathway in vitro followed by direct appendage of D-desosamine and final C-H oxidation(s) in vivo was developed and applied toward the synthesis of a suite of 12-and 14-membered ring mac...

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Main Authors: Hansen, Douglas A., Rath, Christopher M., Eisman, Eli B., Narayan, Alison R. H., Kittendorf, Jeffrey D., Mortison, Jonathan D., Yoon°, Yeo Joon, Sherman, David H.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3771335/
https://ncbi.nlm.nih.gov/pubmed/23866020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja404134f
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