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Structure-Based, Rational Design of T Cell Receptors
Adoptive cell transfer using engineered T cells is emerging as a promising treatment for metastatic melanoma. Such an approach allows one to introduce T cell receptor (TCR) modifications that, while maintaining the specificity for the targeted antigen, can enhance the binding and kinetic parameters...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Frontiers Media S.A.
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3770923/ https://ncbi.nlm.nih.gov/pubmed/24062738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00268 |
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