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Structure-Based Rational Design of a Phosphotriesterase

In silico substrate docking of both stereoisomers of the pesticide chlorfenvinphos (CVP) in the phosphotriesterase from Agrobacterium radiobacter identified two residues (F131 and W132) that prevent productive substrate binding and cause stereospecificity. A variant (W131H/F132A) was designed that e...

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書誌詳細
主要な著者: Jackson, Colin J., Weir, Kahli, Herlt, Anthony, Khurana, Jeevan, Sutherland, Tara D., Horne, Irene, Easton, Christopher, Russell, Robyn J., Scott, Colin, Oakeshott, John G.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725513/
https://ncbi.nlm.nih.gov/pubmed/19502439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00629-09
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