Structure-Based Rational Design of a Phosphotriesterase

In silico substrate docking of both stereoisomers of the pesticide chlorfenvinphos (CVP) in the phosphotriesterase from Agrobacterium radiobacter identified two residues (F131 and W132) that prevent productive substrate binding and cause stereospecificity. A variant (W131H/F132A) was designed that e...

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Détails bibliographiques
Auteurs principaux: Jackson, Colin J., Weir, Kahli, Herlt, Anthony, Khurana, Jeevan, Sutherland, Tara D., Horne, Irene, Easton, Christopher, Russell, Robyn J., Scott, Colin, Oakeshott, John G.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2009
Sujets:
Enzymology and Protein Engineering
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725513/
https://ncbi.nlm.nih.gov/pubmed/19502439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00629-09
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