Structure-Based Rational Design of a Phosphotriesterase

In silico substrate docking of both stereoisomers of the pesticide chlorfenvinphos (CVP) in the phosphotriesterase from Agrobacterium radiobacter identified two residues (F131 and W132) that prevent productive substrate binding and cause stereospecificity. A variant (W131H/F132A) was designed that e...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jackson, Colin J., Weir, Kahli, Herlt, Anthony, Khurana, Jeevan, Sutherland, Tara D., Horne, Irene, Easton, Christopher, Russell, Robyn J., Scott, Colin, Oakeshott, John G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2009
Pynciau:
Enzymology and Protein Engineering
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725513/
https://ncbi.nlm.nih.gov/pubmed/19502439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00629-09
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