The small molecule, genistein, increases hepcidin expression in human hepatocytes

Hepcidin, a peptide hormone that decreases intestinal iron absorption and macrophage iron release, is a potential drug target for patients with iron overload syndromes because its levels are inappropriately low in these individuals. Endogenous stimulants of Hepcidin transcription include bone morpho...

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Bibliographic Details
Main Authors: Zhen, Aileen W, Nguyen, Nancy H, Gibert, Yann, Motola, Shmulik, Buckett, Peter, Wessling-Resnick, Marianne, Fraenkel, Ernest, Fraenkel, Paula G
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2013
Subjects:
Steatohepatitis/Metabolic Liver Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770762/
https://ncbi.nlm.nih.gov/pubmed/23703590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26490
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