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Small-Molecule Screening Identifies the Selanazal Drug Ebselen as a Potent Inhibitor of DMT1-Mediated Iron Uptake

HEK293T cells overexpressing divalent metal transporter-1 (DMT1) were established to screen for small-molecule inhibitors of iron uptake. Using a fluorescence-based assay, we tested 2000 known bioactive compounds to find 3 small molecules that potently block ferrous iron uptake. One of the inhibitor...

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Detaylı Bibliyografya
Asıl Yazarlar: Wetli, Herbert A., Buckett, Peter D., Wessling-Resnick, Marianne
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2006
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2542486/
https://ncbi.nlm.nih.gov/pubmed/16984886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2006.08.005
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