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The Small-Molecule Iron Transport Inhibitor Ferristatin/NSC306711 Promotes Degradation of the Transferrin Receptor
Iron delivery by transferrin (Tf) is accomplished through clathrin-mediated endocytosis of Tf receptors. The small molecule NSC306711 inhibits iron uptake from the Tf-TfR pathway. Here we show that the drug’s mechanism of action is to induce internalization and degradation of unoccupied Tf receptors...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3747564/ https://ncbi.nlm.nih.gov/pubmed/18635001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.05.011 |
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