RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

Receptor-interacting protein kinase (RIPK) 1 and RIPK3 have emerged as essential kinases mediating a regulated form of necrosis, known as necroptosis, that can be induced by tumor necrosis factor (TNF) signaling. As a consequence, inhibiting RIPK1 kinase activity and repressing RIPK3 expression leve...

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Bibliografiske detaljer
Main Authors: Dondelinger, Y, Aguileta, M A, Goossens, V, Dubuisson, C, Grootjans, S, Dejardin, E, Vandenabeele, P, Bertrand, M J M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770330/
https://ncbi.nlm.nih.gov/pubmed/23892367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.94
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