A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors

Histone deacetylase (HDAC) is an emergent anticancer target, and HR23B is a biomarker for response to HDAC inhibitors. We show here that HR23B has impacts on two documented effects of HDAC inhibitors; HDAC inhibitors cause apoptosis in cells expressing high levels of HR23B, whereas in cells with low...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: New, M, Olzscha, H, Liu, G, Khan, O, Stimson, L, McGouran, J, Kerr, D, Coutts, A, Kessler, B, Middleton, M, La Thangue, N B
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770323/
https://ncbi.nlm.nih.gov/pubmed/23703321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.47
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados