A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors

Histone deacetylase (HDAC) is an emergent anticancer target, and HR23B is a biomarker for response to HDAC inhibitors. We show here that HR23B has impacts on two documented effects of HDAC inhibitors; HDAC inhibitors cause apoptosis in cells expressing high levels of HR23B, whereas in cells with low...

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Autors principals: New, M, Olzscha, H, Liu, G, Khan, O, Stimson, L, McGouran, J, Kerr, D, Coutts, A, Kessler, B, Middleton, M, La Thangue, N B
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770323/
https://ncbi.nlm.nih.gov/pubmed/23703321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.47
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