Pharmacological Activity of Retinoic Acid Receptor Alpha-Selective Antagonists in Vitro and in Vivo

[Image: see text] Oral administration of a retinoic acid receptor (RAR) pan-antagonist reversibly inhibits spermatogenesis. Given the importance of RARα in regulating spermatogenesis, we identified two RARα-selective antagonists by transactivation and transactivation competition assays and asked whe...

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Main Authors: Chung, Sanny S. W., Cuellar, Rebecca A. D., Wang, Xiangyuan, Reczek, Peter R., Georg, Gunda I., Wolgemuth, Debra J.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2013
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770188/
https://ncbi.nlm.nih.gov/pubmed/24040487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300365k
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