Oral Administration of a Retinoic Acid Receptor Antagonist Reversibly Inhibits Spermatogenesis in Mice

Here we investigated a pharmacological approach to inhibit spermatogenesis in the mouse model by manipulating retinoid signaling using low doses of the pan-retinoic acid receptor (RAR) antagonist BMS-189453. Spermatogenesis was disrupted, with a failure of spermatid alignment and sperm release and l...

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Autores principales: Chung, Sanny S. W., Wang, Xiangyuan, Roberts, Shelby S., Griffey, Stephen M., Reczek, Peter R., Wolgemuth, Debra J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2011
Materias:
Reproduction-Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100616/
https://ncbi.nlm.nih.gov/pubmed/21505053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0941
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