Myeloproliferative Neoplasia Remodels the Endosteal Bone Marrow Niche into a Self-Reinforcing Leukemic Niche

Multipotent stromal cells (MSC) and their osteoblastic lineage cell (OBC) derivatives are part of the BM niche and contribute to hematopoietic stem cells (HSC) maintenance. Here, we show that myeloproliferative neoplasia (MPN) progressively remodels the endosteal BM niche into a self-reinforcing leu...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Schepers, Koen, Pietras, Eric M., Reynaud, Damien, Flach, Johanna, Binnewies, Mikhail, Garg, Trit, Wagers, Amy J., Hsiao, Edward C., Passegué, Emmanuelle
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769504/
https://ncbi.nlm.nih.gov/pubmed/23850243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2013.06.009
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