Myeloproliferative Neoplasia Remodels the Endosteal Bone Marrow Niche into a Self-Reinforcing Leukemic Niche

Multipotent stromal cells (MSC) and their osteoblastic lineage cell (OBC) derivatives are part of the BM niche and contribute to hematopoietic stem cells (HSC) maintenance. Here, we show that myeloproliferative neoplasia (MPN) progressively remodels the endosteal BM niche into a self-reinforcing leu...

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Main Authors: Schepers, Koen, Pietras, Eric M., Reynaud, Damien, Flach, Johanna, Binnewies, Mikhail, Garg, Trit, Wagers, Amy J., Hsiao, Edward C., Passegué, Emmanuelle
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769504/
https://ncbi.nlm.nih.gov/pubmed/23850243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2013.06.009
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