IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development

Using a mouse model recapitulating the main features of human chronic myelogenous leukemia (CML), we uncover the hierarchy of leukemic stem and progenitor cells contributing to disease pathogenesis. We refine the characterization of CML leukemic stem cells (LSCs) to the most immature long-term hemat...

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Autores principales: Reynaud, Damien, Pietras, Eric, Barry-Holson, Keegan, Mir, Alain, Binnewies, Mikhail, Jeanne, Marion, Sala-Torra, Olga, Radich, Jerald P., Passegué, Emmanuelle
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220886/
https://ncbi.nlm.nih.gov/pubmed/22094259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.10.012
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