Small Molecule Regulation of Protein Conformation by Binding in the Flap of HIV Protease

The fragment indole-6-carboxylic acid (1F1), previously identified as a flap site binder in a fragment-based screen against HIV protease (PR), has been co-crystallized with pepstatin-inhibited PR and with apo-PR. Another fragment, 3-indolepropionic acid (1F1-N), predicted by AutoDock calculations an...

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Hlavní autoři: Tiefenbrunn, Theresa, Forli, Stefano, Baksh, Michael M., Chang, Max W., Happer, Meaghan, Lin, Ying-Chuan, Perryman, Alexander L., Rhee, Jin-Kyu, Torbett, Bruce E., Olson, Arthur J., Elder, John H., Finn, M. G., Stout, C. David
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769432/
https://ncbi.nlm.nih.gov/pubmed/23540839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300611p
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