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High-dose rapamycin blocks mossy fiber sprouting but not seizures in a mouse model of temporal lobe epilepsy

PURPOSE: The role of granule cell axon (mossy fiber) sprouting in temporal lobe epileptogenesis is unclear and controversial. Rapamycin suppresses mossy fiber sprouting, but its reported effects on seizure frequency are mixed. The present study used high-dose rapamycin to more completely block mossy...

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書誌詳細
主要な著者: Heng, Kathleen, Haney, Megan M., Buckmaster, Paul S.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769425/
https://ncbi.nlm.nih.gov/pubmed/23848506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.12246
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