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Rapamycin Suppresses Mossy Fiber Sprouting But Not Seizure Frequency in a Mouse Model of Temporal Lobe Epilepsy

Temporal lobe epilepsy is prevalent and can be difficult to treat effectively. Granule cell axon (mossy fiber) sprouting is a common neuropathological finding in patients with mesial temporal lobe epilepsy, but its role in epileptogenesis is unclear and controversial. Focally infused or systemic rap...

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Detalhes bibliográficos
Main Authors: Buckmaster, Paul S., Lew, Felicia H.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073836/
https://ncbi.nlm.nih.gov/pubmed/21307269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4852-10.2011
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