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HDAC6 inhibition restores ciliary expression and decreases tumor growth

Primary cilia are multisensory organelles recently found to be absent in some tumor cells, but the mechanisms of deciliation and the role of cilia in tumor biology remain unclear. Cholangiocytes, the epithelial cells lining the biliary tree, normally express primary cilia and their interaction with...

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Detalhes bibliográficos
Main Authors: Gradilone, Sergio A, Radtke, Brynn N, Bogert, Pamela S, Huang, Bing Q, Gajdos, Gabriella B, LaRusso, Nicholas F
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3768151/
https://ncbi.nlm.nih.gov/pubmed/23370327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2938
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