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HDAC6 inhibition restores ciliary expression and decreases tumor growth

Primary cilia are multisensory organelles recently found to be absent in some tumor cells, but the mechanisms of deciliation and the role of cilia in tumor biology remain unclear. Cholangiocytes, the epithelial cells lining the biliary tree, normally express primary cilia and their interaction with...

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Autori principali: Gradilone, Sergio A, Radtke, Brynn N, Bogert, Pamela S, Huang, Bing Q, Gajdos, Gabriella B, LaRusso, Nicholas F
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3768151/
https://ncbi.nlm.nih.gov/pubmed/23370327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2938
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