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Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses
Viral and pharmacologic inducers of PKR-like ER kinase (PERK) were shown to accelerate the phosphorylation-dependent degradation of the IFNAR1 chain of the type 1 interferon (IFN) receptor and to limit cell sensitivity to IFN. Here we report that hypoxia can elicit these effects in a PERK-dependent...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3766494/ https://ncbi.nlm.nih.gov/pubmed/23045272 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.439 |
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