Inducible Priming Phosphorylation Promotes Ligand-independent Degradation of the IFNAR1 Chain of Type I Interferon Receptor

Phosphorylation-dependent ubiquitination and ensuing down-regulation and lysosomal degradation of the interferon α/β receptor chain 1 (IFNAR1) of the receptor for Type I interferons play important roles in limiting the cellular responses to these cytokines. These events could be stimulated either by...

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Main Authors: Bhattacharya, Sabyasachi, HuangFu, Wei-Chun, Liu, Jianghuai, Veeranki, Sudhakar, Baker, Darren P., Koumenis, Constantinos, Diehl, J. Alan, Fuchs, Serge Y.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807289/
https://ncbi.nlm.nih.gov/pubmed/19948722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.071498
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