Virus-induced unfolded protein response attenuates anti-viral defenses via phosphorylation-dependent degradation of the Type I interferon receptor

Phosphorylation-dependent ubiquitination and degradation of the IFNAR1 chain of Type I interferon (IFN) receptor is regulated by two different pathways one of which is ligand-independent. We report that this pathway is activated by inducers of the endoplasmic reticulum (ER) stress, including viral i...

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Detalhes bibliográficos
Main Authors: Liu, Jianghuai, HuangFu, Wei-Chun, Kumar, K.G. Suresh, Qian, Juan, Casey, James P., Hamanaka, Robert B., Grigoriadou, Christina, Aldabe, Rafael, Diehl, J. Alan, Fuchs, Serge Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741731/
https://ncbi.nlm.nih.gov/pubmed/19154989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2008.11.008
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