Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses

Viral and pharmacologic inducers of PKR-like ER kinase (PERK) were shown to accelerate the phosphorylation-dependent degradation of the IFNAR1 chain of the type 1 interferon (IFN) receptor and to limit cell sensitivity to IFN. Here we report that hypoxia can elicit these effects in a PERK-dependent...

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Bibliographic Details
Main Authors: Bhattacharya, Sabyasachi, HuangFu, Wei-Chun, Dong, Guangyu, Qian, Juan, Baker, Darren P., Karar, Jayashree, Koumenis, Constantinos, Diehl, J. Alan, Fuchs, Serge Y.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3766494/
https://ncbi.nlm.nih.gov/pubmed/23045272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.439
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