Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen

BACKGROUND: Guanylate Cyclase C (GC-C) is an apically-oriented transmembrane receptor that is expressed on epithelial cells of the intestine. Activation of GC-C by the endogenous ligands guanylin or uroguanylin elevates intracellular cGMP and is implicated in intestinal ion secretion, cell prolifera...

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Bibliographic Details
Main Authors: Mann, Elizabeth A, Harmel-Laws, Eleana, Cohen, Mitchell B, Steinbrecher, Kris A
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3766218/
https://ncbi.nlm.nih.gov/pubmed/24004613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-230X-13-135
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