Functional Identification of the Mouse Circadian Clock Gene by Transgenic BAC Rescue

As a complementary approach to positional cloning, we used in vivo complementation with bacterial artificial chromosome (BAC) clones expressed in transgenic mice to identify the circadian Clock gene. A 140 kb BAC transgene completely rescued both the long period and the loss-of-rhythm phenotypes in...

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Autores principales: Antoch, Marina P., Song, Eun-Joo, Chang, Anne-Marie, Vitaterna, Martha Hotz, Zhao, Yaliang, Wilsbacher, Lisa D., Sangoram, Ashvin M., King, David P., Pinto, Lawrence H., Takahashi, Joseph S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 1997
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764491/
https://ncbi.nlm.nih.gov/pubmed/9160756
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