Mutagenesis and Mapping of a Mouse Gene, Clock, Essential for Circadian Behavior

In a search for genes that regulate circadian rhythms in mammals, the progeny of mice treated with Nethyl-N-nitrosourea (ENU) were screened for circadian clock mutations. A semidominant mutation, Clock, that lengthens circadian period and abolishes persistence of rhythmicity was identified. Clock se...

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Main Authors: Vitaterna, Martha Hotz, King, David P., Chang, Anne-Marie, Kornhauser, Jon M., Lowrey, Phillip L., McDonald, J. David, Dove, William F., Pinto, Lawrence H., Turek, Fred W., Takahashi, Joseph S.
Format: Artigo
Jezik:Inglês
Izdano: 1994
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839659/
https://ncbi.nlm.nih.gov/pubmed/8171325
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