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Deacetylation by SIRT1 Reprograms Inflammation and Cancer
NAD(+)-dependent deacetylase SIRT1 is a master regulator of nucleosome positioning and chromatin structure, thereby reprogramming gene expression. In acute inflammation, chromatin departs from, and returns to, homeostasis in an orderly sequence. This sequence depends on shifts in NAD(+) availability...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
SAGE Publications
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3764465/ https://ncbi.nlm.nih.gov/pubmed/24020005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601913476948 |
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