VAPB/ALS8 MSP Ligands Regulate Striated Muscle Energy Metabolism Critical for Adult Survival in Caenorhabditis elegans

Mutations in VAPB/ALS8 are associated with amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), two motor neuron diseases that often include alterations in energy metabolism. We have shown that C. elegans and Drosophila neurons secrete a cleavage product of VAPB, the N-terminal maj...

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Detalhes bibliográficos
Main Authors: Han, Sung Min, El Oussini, Hajer, Scekic-Zahirovic, Jelena, Vibbert, Jack, Cottee, Pauline, Prasain, Jeevan K., Bellen, Hugo J., Dupuis, Luc, Miller, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764199/
https://ncbi.nlm.nih.gov/pubmed/24039594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003738
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