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The Rapamycin-Binding Domain of the Protein Kinase mTOR is a Destabilizing Domain
Rapamycin is an immunosuppressive drug that binds simultaneously to the 12-kDa FK506- and rapamycin-binding protein (FKBP12, or FKBP) and the FKBP-rapamycin binding domain (FRB) of the mammalian target of rapamycin (mTOR) kinase. The resulting ternary complex has been used to conditionally perturb p...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3763840/ https://ncbi.nlm.nih.gov/pubmed/17350953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M700498200 |
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