APOE3, but Not APOE4, Bone Marrow Transplantation Mitigates Behavioral and Pathological Changes in a Mouse Model of Alzheimer Disease

Apolipoprotein E4 (APOE4) genotype is the strongest genetic risk factor for late-onset Alzheimer disease and confers a proinflammatory, neurotoxic phenotype to microglia. Here, we tested the hypothesis that bone marrow cell APOE genotype modulates pathological progression in experimental Alzheimer d...

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Detalhes bibliográficos
Main Authors: Yang, Yue, Cudaback, Eiron, Jorstad, Nikolas L., Hemingway, Jake F., Hagan, Catherine E., Melief, Erica J., Li, Xianwu, Yoo, Tom, Khademi, Shawn B., Montine, Kathleen S., Montine, Thomas J., Keene, C. Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2013
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763765/
https://ncbi.nlm.nih.gov/pubmed/23831297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.05.009
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