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Influence of CYP2B6 genetic variants on plasma and urine concentrations of bupropion and metabolites at steady state

BACKGROUND: Bupropion, an antidepressant and smoking cessation medication, is metabolized to hydroxybupropion (HB), an active metabolite, primarily by CYP2B6. OBJECTIVES: To compare plasma concentrations of bupropion and metabolites at steady state in healthy volunteers with and without CYP2B6 genet...

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Bibliografiske detaljer
Main Authors: Benowitz, Neal L., Zhu, Andy Z. X., Tyndale, Rachel F., Dempsey, Delia, Jacob, Peyton
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763712/
https://ncbi.nlm.nih.gov/pubmed/23344581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32835d9ab0
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