Effect of race and glucuronidation rates on the relationship between nicotine metabolite ratio and nicotine clearance

OBJECTIVES: To investigate if the nicotine metabolite ratio (NMR, the ratio of nicotine metabolites 3’-hydroxycotinine/cotinine) is a reliable phenotypic biomarker for nicotine clearance across races, and as a function of differences in the rate of nicotine, cotinine and 3’-hydroxycotinine glucuroni...

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Bibliographic Details
Published in:Pharmacogenet Genomics
Main Authors: Liakoni, Evangelia, Tyndale, Rachel F, Jacob, Peyton, Dempsey, Delia A, Addo, Newton, Benowitz, Neal L
Format: Artigo
Language:Inglês
Published: 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8184575/
https://ncbi.nlm.nih.gov/pubmed/33675323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000427
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