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The p53 Pathway as a Target in Cancer Therapeutics: Obstacles and Promise
A large fraction of human tumors carry p53 mutations, which allow tumor initiation and progression; furthermore, it is now clear that restoration or reactivation of wild-type p53 function prompts rapid elimination of tumors. The discovery and design of compounds that reactivate or enhance the p53 pa...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3763710/ https://ncbi.nlm.nih.gov/pubmed/21209413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3001366 |
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