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The p53 Pathway as a Target in Cancer Therapeutics: Obstacles and Promise

A large fraction of human tumors carry p53 mutations, which allow tumor initiation and progression; furthermore, it is now clear that restoration or reactivation of wild-type p53 function prompts rapid elimination of tumors. The discovery and design of compounds that reactivate or enhance the p53 pa...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Mandinova, Anna, Lee, Sam W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763710/
https://ncbi.nlm.nih.gov/pubmed/21209413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3001366
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