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Mixed Proteasomes Function To Increase Viral Peptide Diversity and Broaden Antiviral CD8(+) T Cell Responses

The three proteasome subunits with proteolytic activity are encoded by standard or immunoproteasome genes. Many proteasomes expressed by normal cells and cells exposed to cytokines are “mixed”, that is, contain both standard and immunoproteasome subunits. Using a panel of 38 defined influenza A viru...

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Autores principales: Zanker, Damien, Waithman, Jason, Yewdell, Jonathan W., Chen, Weisan
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762975/
https://ncbi.nlm.nih.gov/pubmed/23709680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300802
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