Pseudomonas aeruginosa Exotoxin Y-Mediated Tau Hyperphosphorylation Impairs Microtubule Assembly in Pulmonary Microvascular Endothelial Cells

Pseudomonas aeruginosa uses a type III secretion system to introduce the adenylyl and guanylyl cyclase exotoxin Y (ExoY) into the cytoplasm of endothelial cells. ExoY induces Tau hyperphosphorylation and insolubility, microtubule breakdown, barrier disruption and edema, although the mechanism(s) res...

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Autors principals: Balczon, Ron, Prasain, Nutan, Ochoa, Cristhiaan, Prater, Jason, Zhu, Bing, Alexeyev, Mikhail, Sayner, Sarah, Frank, Dara W., Stevens, Troy
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762819/
https://ncbi.nlm.nih.gov/pubmed/24023939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074343
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