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A Dual Task for the Xbp1-responsive OS-9 Variants in the Mammalian Endoplasmic Reticulum: Inhibiting Secretion of Misfolded Protein Conformers and Enhancing their Disposal
Normally, non-native polypeptides are not transported through the secretory pathway. Rather, they are translocated from the endoplasmic reticulum (ER) lumen into the cytosol where they are degraded by proteasomes. Here we characterize the function in ER quality control of two proteins derived from a...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Biochemistry and Molecular Biology
2008
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3762559/ https://ncbi.nlm.nih.gov/pubmed/18417469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802272200 |
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