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ERAD and ERAD tuning: disposal of cargo and of ERAD regulators from the mammalian ER
The endoplasmic reticulum (ER) is the site of maturation for secretory and membrane proteins in eukaryotic cells. Unsuccessful folding attempts are eventually interrupted and most folding-defective polypeptides are dislocated across the ER membrane and degraded by cytosolic proteasomes in a complex...
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| Publicado en: | Curr Opin Cell Biol |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Elsevier Ltd.
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7172097/ https://ncbi.nlm.nih.gov/pubmed/21075612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceb.2010.10.002 |
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