Constitutive Production of NF-κB2 p52 Is Not Tumorigenic but Predisposes Mice to Inflammatory Autoimmune Disease by Repressing Bim Expression

Normal development of the immune system requires regulated processing of NF-κB2 p100 to p52, which activates NF-κB2 signaling. Constitutive production of p52 has been suggested as a major mechanism underlying lymphomagenesis induced by NF-κB2 mutations, which occur recurrently in a variety of human...

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Bibliographic Details
Main Authors: Wang, Zhe, Zhang, Baochun, Yang, Liqun, Ding, Jane, Ding, Han-Fei
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762532/
https://ncbi.nlm.nih.gov/pubmed/18281283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800806200
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