Loss of Negative Feedback Control of Nuclear Factor-κB2 Activity in Lymphocytes Leads to Fatal Lung Inflammation

Proteolytic processing of the nuclear factor (NF)-κB2 precursor protein p100 generates the active NF-κB2 subunit p52, which in turn transcriptionally up-regulates p100 expression. p100 also functions as an IκB molecule capable of repressing p52 activity. The biological significance of this negative...

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Detalhes bibliográficos
Main Authors: Yang, Liqun, Cui, Hongjuan, Wang, Zhe, Zhang, Baochun, Ding, Jane, Liu, Lin, Ding, Han-Fei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877828/
https://ncbi.nlm.nih.gov/pubmed/20363924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090751
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