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Src Family Kinase Inhibitor PP2 Induces LC3 Conversion in a Manner That is Uncoupled from Autophagy and Increases Apoptosis in Multidrug-Resistant Cells

Recently, we reported that defective autophagy may contribute to the inhibition of the growth in response to PP2 (4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine), a selective SFK inhibitor, in multidrug-resistant v-Ha-ras-transformed NIH 3T3 cells (Ras-NIH 3T3/Mdr). In this study, w...

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Detalhes bibliográficos
Main Authors: Kim, Yun-Ki, Ahn, Jun-Ho, Lee, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Society of Applied Pharmacology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762265/
https://ncbi.nlm.nih.gov/pubmed/24009826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2012.20.4.393
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