Combined effects of PI3K and SRC kinase inhibitors with imatinib on intracellular calcium levels, autophagy, and apoptosis in CML-PBL cells

Imatinib induces a complete cytogenetic regression in a large percentage of patients affected by chronic myeloid leukemia (CML) until mutations in the kinase domain of BCR-ABL appear. Alternative strategies for CML patients include the inhibition of phosphatidylinositol 3-kinase (PI3K)-Akt-mammalian...

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Main Authors: Ciarcia, Roberto, Damiano, Sara, Montagnaro, Serena, Pagnini, Ugo, Ruocco, Antonio, Caparrotti, Giuseppe, d’Angelo, Danila, Boffo, Silvia, Morales, Fátima, Rizzolio, Flavio, Florio, Salvatore, Giordano, Antonio
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2013
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Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899197/
https://ncbi.nlm.nih.gov/pubmed/23966159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.25920
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