Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies

Human epidermal growth factor receptor 2 (HER2; ERBB2) amplification and phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) mutations often co-occur in breast cancer. Aberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway has been shown to correlate wit...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Hanker, Ariella B., Pfefferle, Adam D., Balko, Justin M., Kuba, María Gabriela, Young, Christian D., Sánchez, Violeta, Sutton, Cammie R., Cheng, Hailing, Perou, Charles M., Zhao, Jean J., Cook, Rebecca S., Arteaga, Carlos L.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2013
विषय:
Biological Sciences
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761610/
https://ncbi.nlm.nih.gov/pubmed/23940356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303204110
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